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Expression of functional HIV-1 integrase in the yeastSaccharomyces cerevisiae leads to the emergence of a lethal phenotype: potential use for inhibitor screening

Lethal PhenotypeMedicineFunctional Hiv-1 IntegrasePathogenesisImmunologyAntiviral Drug DevelopmentHuman RetrovirusVirologyYeastAntiviral ResponseMicrobiologyHivSystems BiologyInhibitor ScreeningAids PathogenesisDrug Resistance