Archives of Ophthalmology · 2007 · 55 citations · 12 references
MedicineEndocrinologyPharmacologyClinical PharmacologyOcular PharmacologyOphthalmic EpidemiologyDiabetes ControlDiabetes MellitusDiabetes PharmacotherapyDiabetes PreventionDiabetic RetinopathyDiabetic Retinopathy EpidemiologyCase-control Study DesignDiabetes DurationDiabetic Retinopathy IncidenceDiabetic Retinopathy ProgressionHmg-coa Reductase InhibitorsIncidence Density SamplingNested Case-control DesignOdds Ratio Modeling
OBJECTIVE: To investigate whether hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) prevent the development of diabetic retinopathy. METHODS: We conducted a nested case-control study among patients at the Birmingham Veterans Affairs Medical Center, Birmingham, Alabama. Within a study population of male diabetic patients (n=6441), we identified incident cases of diabetic retinopathy diagnosed between January 1, 1997, and December 31, 2001 (n=114). Control subjects were selected using incidence density sampling and were matched for diabetes duration. Information regarding filled statin prescriptions was obtained for cases and controls. RESULTS: Cases and controls did not differ regarding overall statin use in crude analysis (odds ratio, 1.01; 95% confidence interval, 0.64-1.59) and in multivariate analyses adjusted for age, race, and coexisting medical conditions (odds ratio, 1.00; 95% confidence interval, 0.60-1.67). CONCLUSION: The results of this study do not support an association between statins and diabetic retinopathy.
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The Prevalence of Diabetic Retinopathy Among Adults in the United States
John H. Kempen, O'Colmain Bj, Leske Mc et al. · Archives of Ophthalmology · 2004 · 1.1K citations
Medicine, Ophthalmology, Diabetology +14
Diabetic Retinopathy in a Multi-ethnic Cohort in the United States
Tien Yin Wong, Ronald Klein, Amirul Islam et al. · American Journal of Ophthalmology · 2006 · 694 citations