13- <i>cis</i> -Retinoic Acid: Inhibition of Bladder Carcinogenesis Induced in Rats by <i>N</i> -Butyl- <i>N</i> -(4-hydroxybutyl)nitrosamine

Abstract

Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.