Acta Psychiatrica Scandinavica · 1987 · 21 citations · 29 references
MedicinePharmacologyPsychiatryEating DisordersNeuroendocrinologyPsychopharmacologyAnorexia NervosaPlatelet ActivationPlatelet FunctionPlatelet PhysiologySerotonergic PharmacologySerotonergic Signaling5-Hydroxytryptamine Receptor PharmacologyControl Group DesignMatched Control GroupPlatelet MetabolismSerotonergic DysregulationSerotonergic MechanismsSerotonin PharmacokineticsSerotonin Turnover
Platelet serotonin (5-HT) uptake was determined in 15 underweight anorexia nervosa patients and a control group of 15 healthy individuals. The Vmax (picomoles/10(8) platelets/5 min) was 424 +/- 103 in patients and 424 +/- 69 in controls. The Km was 1.19 +/- 0.2 microM in patients and 1.08 +/- 0.17 microM in controls. The differences between the groups were not significant. These findings do not support the hypothesis that serotonin metabolism is disturbed in anorexia nervosa.
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Dennis P. Cantwell · Archives of General Psychiatry · 1977 · 370 citations
Medicine, Psychiatry, Psychology +14
Phenomenologic relationship of eating disorders to major affective disorder
James I. Hudson, Harrison G. Pope, Jeffrey M. Jonas et al. · Psychiatry Research · 1983 · 315 citations
Medicine, Psychiatry, Psychology +14