Concepedia

Evidence for Active Immunity to Morphine in Mice

Barry A. Berkowitz, Sydney Spector

Science · 1972 · 104 citations · 9 references

DOI

Concepts

Abstract

The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.

References

9

A Method for Evaluating both Non-Narcotic and Narcotic Analgesics

Estelle A. Siegmund, R. Cadmus, Gongxuan Lü · Experimental Biology and Medicine · 1957 · 493 citations

, , +13

Morphine: Radioimmunoassay

Sydney Spector, Charles W. Parker · Science · 1970 · 212 citations

, , +8

QUANTITATIVE DETERMINATION OF MORPHINE IN SERUM BY RADIOIMMUNOASSAY

Sydney Spector · Journal of Pharmacology and Experimental Therapeutics · 1971 · 119 citations

, , +11

Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide

Horace H. Loh, Fu-Hsiung Shen, E. Leong Way · Biochemical Pharmacology · 1969 · 116 citations

, , +16

Disposition of Morphine in Man

Sydney Spector, Elliott S. Vesell · Science · 1971 · 65 citations

, , +9