Growth Hormone and Prolactin Secretion by a Tumor of the Pharyngeal Pituitary

Abstract

Brief Reports1 January 1982Growth Hormone and Prolactin Secretion by a Tumor of the Pharyngeal PituitaryBARRY A. WARNER, D.O., RICHARD J. SANTEN, M.D., ROBERT B. PAGE, M.D.BARRY A. WARNER, D.O.Search for more papers by this author, RICHARD J. SANTEN, M.D.Search for more papers by this author, ROBERT B. PAGE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEmbryologic remnants of tissue with the potential of pituitary function are seen in the pharyngeal region at autopsy as a consistently normal finding in humans (1). Extrapituitary cells can produce syndromes of endocrine hypersecretion, as documented by five reports of tumors arising from embryonic remnants in the sphenoid sinus (2-6). Two of those caused the clinical syndrome of acromegaly (5, 6). However, four of five of these cases antedated development of sensitive hormone assays. We describe the case of a patient with acromegaly who had a mixed growth hormone and prolactin-secreting tumor arising within the sphenoid sinus. Endocrine testing showed...References1. BOYD J. Observations in the human pharyngeal hypophysis. J Endocrinol. 1956;14:66-7. CrossrefMedlineGoogle Scholar2. GARSHIN W. Ein Fall der intrasphenoidalen Hypophysenganggeschwulst Z Krebsforsch. 1930;31:432-6. CrossrefGoogle Scholar3. BOCK E. Beitrang zur Pathologie der Hypophyse. Virchows Arch Pathol Anat. 1924;252:98-112. CrossrefGoogle Scholar4. RASMUSSEN P and LINDHOLM J. Ectopic pituitary adenomas. Clin Endocrinol (Oxf). 1979; 11:69-74. CrossrefMedlineGoogle Scholar5. ERDHEIM J. Uber einen Hypophysentumor von ungewohn lichem Sitz. Beitr Pathol Anat. 1909;46:233-40. Google Scholar6. CORENBLUM B, LEBLANC F, and WATANABE M. Acromegaly with an adenomatous pharyngeal pituitary. JAMA. 1980;243:1456-7. CrossrefMedlineGoogle Scholar7. MARTYN C and BEVAN J. Bromocriptine in the treatment of acromegaly. Scott Med J. 1980;25:571-4. CrossrefGoogle Scholar8. FROHMAN L, SZABO M, BERELOWITZ M, and STACHURA M. Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly. J Clin Invest. 1980;65:43-54. CrossrefMedlineGoogle Scholar9. NACHTHIGALL R, MONROE S, WILSON C, and JAFFEE R. Prolactin secreting pituitary adenomas in women. Am J Obstet Gynecol. 1981;140:303-8. CrossrefMedlineGoogle Scholar10. DUELLO T and HALMI N. Immunocytochemistry of prolactin-producing human pituitary adenomas. Am J Anat. 1980;158:463-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BARRY A. WARNER, D.O.; RICHARD J. SANTEN, M.D.; ROBERT B. PAGE, M.D.Affiliations: The Milton S. Hershey Medical Center Hershey, Pennsylvania. 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