Silver Acetate/TF‐BiphamPhos‐Catalyzed <i>endo</i>‐Selective Enantioselective 1,3‐Dipolar Cycloaddition of Azomethine Ylides with Vinyl Phenyl Sulfone

Abstract

Abstract The first catalytic endo ‐selective 1,3‐dipolar cycloaddition of azomethine ylides and vinyl phenyl sulfone has been developed successfully. The highly efficient silver acetate (AgOAc)/TF‐BiphamPhos catalytic system exhibited high reactivity, excellent diastereoselectivity (&gt;98:2), good enantioselectivity (67–92% ee ) and broad substrate scope under mild conditions.