Mechanism of membrane depolarization caused by the Alzheimer Aβ1–42 peptide

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

MP Mattson, Bin Cheng, David L. Davis et al. · Journal of Neuroscience · 1992 · 1.6K citations · Full text

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

Thomas J. O’Dell, Eric R. Kandel, Seth G. N. Grant · Nature · 1991 · 520 citations

Synaptic Plasticity, Neurophysiology, Medicine +11

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

Peter T. Lansbury, Philip R. Costa, Janet M. Griffiths et al. · Nature Structural & Molecular Biology · 1995 · 395 citations

Biochemistry, Protein Folding, Medicine +9

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

Mark P. Mattson, Kevin J. Tomaselli, Russell E. Rydel · Brain Research · 1993 · 386 citations

Neurodegenerative Diseases, Alzheimer's Disease, Neurodegenerative Effects +9

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

Nir Osherov, Alexander Levitzki · European Journal of Biochemistry · 1994 · 283 citations

Signal Transduction, Developmental Biology, Signaling Pathway +12