Archives of Environmental Health An International Journal · 2004 · 91 citations · 22 references
Life SciencesGeneticsToxicologyGenetic EpidemiologyHuman GeneticsMedical GeneticsGenotype-phenotype Association AnalysisGlutathione ConjugationGlutathione MetabolismFatty AcidsGlutathione HomeostasisGlutathione S-transferase ActivityGlutathione S-transferasesMetabolic Pathway PolymorphismsUgt1a1 GenotypeUnsaturated Fatty AcidsVariant Allele Frequency Analysis
Methylmercury is eliminated from the human body as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL) and conjugation by glutathione S-transferases (GST). In this study, the authors tested whether polymorphisms in GCL and GST genes modify methylmercury retention. Erythrocyte mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 365 individuals. A general linear model was developed for analyzing whether genotype modified the regression of EryHg on PPUFA. The presence of one variant allele for either GCLC-129 or GSTP1-114 was associated with higher EryHg and steeper regression slope. No similar trends were shown for GCLM, GSTA1, GSTM1, or GSTT1. These findings indicate that GCLC polymorphisms that affect GSH production also affect methylmercury retention, and that GSTP1 may play a role in conjugating methylmercury with GSH.
22
Francis Ali‐Osman, Olanike Akande, Gamil R. Antoun et al. · Journal of Biological Chemistry · 1997 · 722 citations · Full text
Piotr Zimniak, Bindu Nanduri, Sławomir Pikuła et al. · European Journal of Biochemistry · 1994 · 454 citations