Publication | Closed Access
Impact of the <sup>1</sup>H,<sup>15</sup>N-HMBC Experiment on the Constitutional Analysis of Alkaloids
43
Citations
10
References
1999
Year
Bioorganic ChemistryStructural BioinformaticsBiomolecular Structure PredictionMolecular BiologyComputer Program CoconChemical BiologyMedicinal ChemistryBiochemical TaxonomyStructure ElucidationConstitutional AnalysisMolecular DiversityBiochemistryMarine Natural ProductsPharmacologyStructural BiologyBiologyNatural SciencesMedicine1H,15n-hmbc ExperimentDrug DiscoveryDrug Analysis
The 1H,15N-HMBC experiment is a very useful tool for the structure determination of alkaloids. In conjunction with the computer program Cocon, we show how 1H,15N-HMBC-derived connectivity information can assist in the assignment of constitution, by greatly reducing the number of possible structures compatible with a given data set. The method is illustrated for the marine natural products oroidin (1) and manzacidin A (2).
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