HETEROTRANSPLANTATION OF HUMAN ADENOCARCINOMAS OF THE COLON AND RECTUM TO THE MOUSE MUTANT NUDE. A STUDY OF NINE CONSECUTIVE TRANSPLANTATIONS

Abstract

Successful heterotransplantation of 6 out of 9 consecutively transplanted adenocarcinomas of the human colon and rectum to the mouse mutant Nude is reported. Serial growth for 2–8 transfers so far was obtained in 5 cases. The transferred tumours grow locally, and metastatic growth has not been observed with certainty. The histological and cytological appearance of the transferred tumours is in full accordance with that of the primary tumours. The mutant Nude is suggested as a host for human malignant tumours as a basis for the study of tumour growth and for therapeutic assays.