Nucleosides Nucleotides & Nucleic Acids · 2005 · 16 citations · 5 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoverySynthetic Medicinal ChemistryMolecular Targets Of DrugsNucleic Acid Drug DesignNucleobase ChemistryEscherichia ColiNucleoside Analog SynthesisNucleoside AnalogsNucleoside Analogue TherapyPurine AnalogsPurine AnaloguesPurine ChemistrySugar Nucleosides
A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5-position have been synthesised These compounds bear a 5'-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding alpha-linker nucleosides with L-xylose and L-lyxose were also synthesized. All of these compounds have been evaluated for their substrate activity with E. coli PNP.
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