Concepedia

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Katharine M. Irvine, Richard Skoien, Nilesh J. Bokil, Michelle Melino, Gethin Thomas, Dorothy Loo, Brian Gabrielli, Michelle M. Hill, Matthew J. Sweet, Andrew D. Clouston,

World Journal of Gastroenterology · 2014 · 89 citations · 28 references

DOIFull text

Open access

Abstract

Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis.

References

28

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang, Brad T. Sherman, Richard A. Lempicki · Nature Protocols · 2008 · 36.7K citations

, , +15

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4K citations · Full text

, , +13

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue, Lars Zender, Cornelius Miething et al. · Nature · 2007 · 2.4K citations · Full text

, , +13

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Shin Yoshimoto, Tze Mun Loo, Koji Atarashi et al. · Nature · 2013 · 2.1K citations

, , +12

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

Juan Carlos Acosta, Ana O’Loghlen, Ana Banito et al. · Cell · 2008 · 1.7K citations · Full text

, , +8