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Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

Medicinal ChemistryPharmaceutical ChemistryBiochemistryDual InhibitorsMedicineNatural SciencesPharmacological AgentPharmacotherapyAnti-cancer AgentDrug Development5-Lipoxygenase PharmacophorePharmacologyCelecoxib AnalogsDrug Discovery