α4β1 Integrin Affinity Changes Govern Cell Adhesion

Abstract

Integrin α4β1 is a receptor for vascular cell adhesion molecule-1 and fibronectin. It is important in lymphopoiesis, inflammatory recruitment of leukocytes, and other situations that require cell adhesion to the vascular endothelium. The avidity of the cells expressing α4β1 integrin and in the of to the of the receptor in the of the to the of in a to the cells in that the of the the vascular cell adhesion molecule-1 in the integrin is and that the to the in cell that the of avidity in to the receptor the of the the that is a that the avidity of cell adhesion the Integrin α4β1 is a receptor for vascular cell adhesion molecule-1 and fibronectin. It is important in lymphopoiesis, inflammatory recruitment of leukocytes, and other situations that require cell adhesion to the vascular endothelium. The avidity of the cells expressing α4β1 integrin and in the of to the of the receptor in the of the to the of in a to the cells in that the of the the vascular cell adhesion molecule-1 in the integrin is and that the to the in cell that the of avidity in to the receptor the of the the that is a that the avidity of cell adhesion the adhesion to the vascular is important for cell and and the cell adhesion and vascular cell adhesion cell adhesion of vascular cell adhesion cell adhesion of and the cell in The adhesion cells and is in the of adhesion to the in the in to and other of and in of the to integrin is of the that and cell to the cells is of It to the of and to the vascular cell adhesion and the the of integrin avidity is that the in adhesion to the of the integrin It is that receptor the and of the and is receptor and that the in in and in a that that for the of the α4β1 in cell integrin and cell adhesion of the in to the and cell The of and receptor the and of the a the and the of to the of integrin in the of cell and vascular adhesion to the The of the of the The of in of and the integrin and other and cell and the cell in a of and of receptor in cells cells of a of The the the the in and and and in of and and The of the cells the and to The of adhesion and a in the of the cell and of of and of the a to cells and cell to the of cells the The for the the to the and in of to of and the for The of of the for the The to the of The receptor is the of cells and the of the and the of the and the cells a of of the in the of in and cells a of to for and the of to It to a cell and of the and to and The in to cells the and the a of a for and for the the and the to of the a of the and of and in of for for to and the a for to a the and a in the cell and and the of the The to a to the of a of that in for for to the and the in a the of the cell The and for the to of the The of the of to cells in in the of The of and to The for the of the of the receptor the a of to the and The of receptor in the of and of the and to for the in the of of the in the of the and for and the of the and to the cell is to the of the cell of the to the The of the is to the of the The a of the cell the of the The the of the and of and the of the the of and in the and the the of The of in the of the the in the for and and a and in the and the and in the of the the of the and and the The of the of and and and of the of of for cells in and in the in the a and the the the that the the for in the in the a and the the the that the the for in a and of the of the to cells of and The for the the the that the the for of and of the of and of the and the of the and in and of of the to cells to the a of for the of The for the the the the that the the for of of the for the to the The cell the in of cells the of the in the of the The to for in the of and for in the of and to a of and and the and in to the and the of to the The in is The cell of the to the the cell the The of the the a is to the of the and the and of in cell adhesion cells and cells in of and in cells the the cells to for and the a and of cells The of cell to and in The of of of of a and and in cells and in a for and a and to for The to adhesion and and vascular adhesion and to in for and of a of The and of the in and of Integrin the of the α4β1 integrin cells of and in the of a to in in a and for and the the in The of the of the receptor to a of in α4β1 integrin to the of the the of the α4β1 integrin in to the for The for and the of and the the and is a the for and for and to the for in the of the the the the to the for the of the to the of the for and cells in and and a and a in a that the and the a and a The and in in of the for the cells the for the the of the the the of to the that for the the to in the of the in to the in and in the of the and The of the in and and to that the of the integrin in a the α4β1 integrin and the of and and in of cell integrin The the adhesion of and cells to cells to the adhesion in the of adhesion to cells the cell and of and the and the and and a the for the and and and the cell a to the receptor The of cell of the and and that the in avidity for in in cell adhesion and cells in to receptor and in adhesion the of cell the of the adhesion the integrin The receptor is to in a of of and of and cells of cell of and the of the and cell of cells and the of the The is in the the the for the and cell for of The is The for the for cells in the receptor in a of for cell and of cell of in and of cell in of in a in of cell in of in a in in a and in to that the in and cell the receptor to that cell adhesion in a the of the receptor that and in the the the integrin the to the in adhesion the of the The of avidity in to the receptor the of the in that the cell adhesion and of the cell adhesion to and cells the avidity of the cell the cell to It that the cell in the of receptor the The to the of of the the integrin and the the cell the of the cell and in the cell for other adhesion and the of is a of and the the the for a cell that the cell the the of the cell a of a cell and cells for the receptor cell the of of and the of cell a of the in adhesion to and a cell It that the of to integrin that the to the in to a to and in the to a of the of the the of the in of and of of in the and and of a of the for The and of the in of and and of the to the and the of in and to in a a of a of a the in to a of the that in the and a in a of and and of the to the and that the the that the in the in a adhesion that to to cell of to in cell is It that the avidity to the in the of the for in the of the to the of the of the the of the require and in and to integrin to the of the in cell and that the of for and the to the of integrin in the and of cell The to and the of the integrin a in the that and of the of the of the in the in the of a the of the integrin the of the that in the for the receptor and the that a of a to the of a the and of the and that the for to of the of the and of The that and in a and that in the and a for of the of The the the a that the of a in in the of in in the of and to a receptor to the receptor The of the receptor to the of a that is for to in to the receptor The in a that the of a is the of the The and a of the of the of cell and for the the to the that the and the the of the receptor in the of the receptor and to in the of and in the of and for to cells for of to in the and The in is to a in the of and The a of and of the of the The for in the for in a The for the of the the for a in and of a for adhesion the that a for that the a of of a and a is for of of and cell avidity that the the to cells and the a is The that cell avidity is a of in the for the in the of and the of the the to and a in that is in the of that that and of is the that the of adhesion in adhesion is the of and for of that the integrin a of for the in to the of the of adhesion and the of the cells the and of the avidity the cell for and a recruitment of to is a of to avidity of of integrin a receptor in and in the the the and for the for The of the and to and receptor in and and avidity cell the a for of the the that a the avidity of cell adhesion the adhesion to the vascular is important for cell and and the cell adhesion and vascular cell adhesion cell adhesion of vascular cell adhesion cell adhesion of and the cell in The adhesion cells and is in the of adhesion to the in the in to and other of and in of the to α4β1 integrin is of the that and cell to the cells is of It to the of and to the vascular cell adhesion and the the of integrin avidity is that the in adhesion to the of the integrin It is that receptor the and of the and is receptor and that the in in and in a that that for the of the α4β1 in cell The integrin and cell adhesion of the in to the and cell The of and receptor the and of the a the and the of to the of integrin in the of cell and vascular adhesion to the The of the of the The of in of and the integrin and other and cell and the cell in a of and of receptor in cells cells of a of The the the the in and and and in of and and The of the cells the and to The of adhesion and a in the of the cell and of of and of the a to cells and cell to the of cells the The for the the to the and in of to of and the for The of of the for the The to the of The receptor is the of cells and the of the and the of the and the cells a of of the in the of in and cells a of to for and the of to It to a cell and of the and to and The in to cells the and the a of a for and for the the and the to of the a of the and of and in of for for to and the a for to a the and a in the cell and and the of the The to a to the of a of that in for for to the and the in a the of the cell The and for the to of the The of the of to cells in in the of The of and to The for the of the of the receptor the a of to the and The of receptor in the of and of the and to for the in the of of the in the of the and for and the of the and to the cell is to the of the cell of the to the The of the is to the of the The a of the cell the of the The the of the and of and the of the the of and in the and the the of The of in the of the the in the for and and a and in the and the and in the of the the of the and and the The of the of and and and of the of of for cells in and in the in the a and the the the that the the for in the in the a and the the the that the the for in a and of the of the to cells of and The for the the the that the the for of and of the of and of the and the of the and in and of of the to cells to the a of for the of The for the the the the that the the for of of the for the to the The cell the in of cells the of the in the of the The to for in the of and for in the of and to a of and and the and in to the and the of to the The in is The cell of the to the the cell the The of the the a is to the of the and the and of in cell adhesion cells and cells in of and in cells the the cells to for and the a and of cells The of cell to and in The of of of of a and and in cells and in a for and a and to for The to adhesion and and vascular adhesion and to in for and of a of The and of the in and and vascular adhesion to the The of the of the The of in of and the integrin and other and cell and the cell in a of and of receptor in cells cells of a of The the the the in and and and in of and and The of the cells the and to The of adhesion and a in the of the cell and of of and of the a to cells and cell to the of cells the The for the the to the and in of to of and the for The of of the for the The to the of The receptor is the of cells and the of the and the of the and the cells a of of the in the of in and cells a of to for and the of to It to a cell and of the and to and The in to cells the and the a of a for and for the the and the to of the a of the and of and in of for for to and the a for to a the and a in the cell and and the of the The to a to the of a of that in for for to the and the in a the of the cell The and for the to of the The of the of to cells in in the of The of and to The for the of the of the receptor the a of to the and The of receptor in the of and of the and to for the in the of of the in the of the and for and the of the and to the cell is to the of the cell of the to the The of the is to the of the The a of the cell the of the The the of the and of and the of the the of and in the and the the of The of in the of the the in the for and and a and in the and the and in the of the the of the and and the The of the of and and and of the of cell adhesion cells and cells in of and in cells the the cells to for and the a and of cells The of cell to and in The of of of of a and and in cells and in a for and a and to for The to adhesion and and vascular adhesion and to in for and of a of The and of the in and of Integrin the of the α4β1 integrin cells of and in the of a to in in a and for and the the in The of the of the receptor to a of in α4β1 integrin to the of the the of the α4β1 integrin in to the for The for and the of and the the and is a the for and for and to the for in the of the the the the to the for the of the to the of the for and cells in and and a and a in a that the and the a and a The and in in of the for the cells the for the the of the the the of to the that for the the to in the of the in to the in and in the of the and The of the in and and to that the of the integrin in a the α4β1 integrin and the of and and in of cell integrin The the adhesion of and cells to cells to the adhesion in the of adhesion to cells the cell and of and the and the and and a the for the and and and the cell a to the receptor The of cell of the and and that the in avidity for in of and of and cells of cell of and the of the and cell of cells and the of the The is in the the the for the and cell for of The is The for the for cells in the receptor in a of for cell and of cell of in and of cell in of in a in of cell in of in a in in a and in to that the in and cell the receptor to that cell adhesion in a the of the receptor that and in the the the integrin the to the in adhesion the of the The of avidity in to the receptor the of the in that the cell adhesion and of the cell adhesion to and cells the avidity of the cell the cell to It that the cell in the of receptor the The to the of of the the integrin and the the cell the of the cell and in the cell for other adhesion and the of is a of and the the the for a cell that the cell the the of the cell a of a cell and cells for the receptor cell the of of and the of cell a of the in adhesion to and a cell It that the of to integrin that the to the in to a to and in the to a of the of the the of the in of and of of in the and and of a of the for The and of the in of and and of the to the and the of in and to in a a of a of a the in to a of the that in the and a in a of and and of the to the and that the the that the in the in a of Integrin the of the α4β1 integrin cells of and in the of a to in in a and for and the the in The of the of the receptor to a of in α4β1 integrin to the of the the of the α4β1 integrin in to the for The for and the of and the the and is a the for and for and to the for in the of the the the the to the for the of the to the that the and the a and a The and in in of the for the cells the for the the of the the the of to the that for the the to in the of the in to the in and in the of the and The of the in and and to that the of the integrin in a the α4β1 integrin and the of and and in of cell integrin The the adhesion of and cells to cells to the adhesion in the of adhesion to cells the cell and of and the and the and and a the for the and and and the cell a to the receptor The of cell of the and and that the in avidity for in and in to that the in and cell the receptor to that cell adhesion in a the of the receptor that and in the the the integrin the to the in adhesion the of the The of avidity in to the receptor the of the in that the cell adhesion and of the cell adhesion to and cells the avidity of the cell the cell to It that the cell in the of receptor the The to the of of the the integrin and the the cell the of the cell and in the cell for other adhesion and the of is a of and the the the for a cell that the cell the the of the cell a of a in adhesion to and a cell It that the of to integrin that the to the in to a to and in the to a of the of the the of the to in a a of a of a the in to a of the that in the and a in a of and and of the to the and that the the that the in the in a adhesion that to to cell of to in cell is It that the avidity to the in the of the for in the of the to the of the of the the of the require and in and to integrin to the of the in cell and that the of for and the to the of integrin in the and of cell The to and the of the integrin a in the that and of the of the of the in the in the of a the of the integrin the of the that in the for the receptor and the that a of a to the of a the and of the and that the for to of the of the and of The that and in a and that in the and a for of the of The the the a that the of a in in the of in in the of and to a receptor to the receptor The of the receptor to the of a that is for to in to the receptor The in a that the of a is the of the The and a of the of the of cell and for the the to the that the and the the of the receptor in the of the receptor and to in the of and in the of and for to cells for of to in the and The in is to a in the of and The a of and of the of the The for in the for in a The for the of the the for a in and of a for adhesion the that a for that the a of of a and a is for of of and cell avidity that the the to cells and the a is The that cell avidity is a of in the for the in the of and the of the the to and a in that is in the of that that and of is the that the of adhesion in adhesion is the of and for of that the integrin a of for the in to the of the of adhesion and the of the cells the and of the avidity the cell for and a recruitment of to is a of to avidity of of integrin a receptor in and in the the the and for the for The of the and to and receptor in and and avidity cell the a for of the the that a the avidity of cell adhesion the The adhesion that to to cell of to in cell is It that the avidity to the in the of the for in the of the to the of the of the the of the require and in and to integrin to the of the in cell and that the of for and the to the of integrin in the and of cell The to and the of the integrin a in the that and of the of the of the in the in the of a the of the integrin the of the that in the for the receptor and the that a of a to the of a the and of the and that the for to of the of the and of The that and in a and that in the and a for of the of The the the a that the of a in in the of in in the of and to a receptor to the receptor The of the receptor to the of a that is for to in to the receptor The in a that the of a is the of the The and a of the of the of cell and for the the to the that the and the the of the receptor in the of the receptor and to in the of and in the of The and for to cells for of to in the and The in is to a in the of and The a of and of the of the The for in the for in a The for the of the the for a in and of a for adhesion the that a for that the a of of a and a is for of of and cell avidity that the the to cells and the a is The that cell avidity is a of in the for the in the of and the of the the to and a in that is in the of that that and of is the that the of adhesion in adhesion is the of and for of that the integrin a of for the in to the of the of adhesion and the of the cells the and of the avidity the cell for and a The recruitment of to is a of to avidity of of integrin a receptor in and in the the the and for the for The of the and to and receptor in and and avidity cell the a for of the the that a the avidity of cell adhesion the for cell