APPEARANCE OF A BRAIN SPECIFIC ANTIGEN (THE S‐100 PROTEIN) DURING HUMAN FOETAL DEVELOPMENT¹

Abstract

Abstract —The concentration of a protein specific to brain, the S‐100 protein, was measured in various regions of the human foetal brain at gestational ages ranging from 10 weeks until term. The relative increase in concentrations of the S‐100 protein during development of the human foetal brain proceeded in a caudal‐rostral fashion. This observation is emphasized by the delayed appearance of the S‐100 protein in the frontal cerebral cortex until the 30th week of gestation.