Synthesis, characterization and antimicrobial activities of transition metal complexes of <b> <i>N,N</i> </b>-dialkyl-<b> <i>N′</i> </b>-(2-chlorobenzoyl)thiourea derivatives

Abstract

N,N-di-n-propyl-N′-(2-chlorobenzoyl)thiourea (HL1) (1), N,N-diphenyl-N′-(2-chlorobenzoyl)thiourea (HL2) (2), and their NiII, CoII, CuII, ZnII, PtII, CdII and PdII complexes have been synthesized and characterized. HL1 and its copper complex were characterized by single-crystal X-ray diffraction methods. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The complexes were screened for their in vitro antibacterial, antifungal activities and toxicity. All compounds showed antimicrobial activity, but antibacterial efficacy is greater than antifungal activity.