Concepedia

A new look at the hemolytic effect of local anesthetics, considering their real membrane/water partitioning at pH 7.4

Sônia Valéria Pinheiro Malheiros, Luciana de Matos Alves Pinto, Luciane Gottardo, Daniela Kiyoko Yokaichiya, Leonardo Fernandes Fraceto, Nilce Correa Meirelles, Eneida de Paula

Biophysical Chemistry · 2004 · 54 citations · 32 references

DOI

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32

Molecular Determinants of State-Dependent Block of Na <sup>+</sup> Channels by Local Anesthetics

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Science · 1994 · 855 citations

Expression of functional sodium channels from cloned cDNA

Masaharu Noda, Takayuki Ikeda, Harukazu Suzuki et al. · Nature · 1986 · 535 citations

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Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

David S. Ragsdale, Jancy C. McPhee, Todd Scheuer et al. · Proceedings of the National Academy of Sciences · 1996 · 497 citations · Full text

, , +24

THE SITE OF ACTION AND ACTIVE FORM OF LOCAL ANESTHETICS. I. THEORY AND pH EXPERIMENTS WITH TERTIARY COMPOUNDS

Toshio Narahashi, D. T. Frazier, Minoru Yamada · Journal of Pharmacology and Experimental Therapeutics · 1970 · 220 citations

Local Anesthetics: Mechanisms of Action and Clinical Use

D. B. McNair Scott · British Journal of Anaesthesia · 1976 · 177 citations · Full text

, , +8