Phenytoin and Cyclosporin A Suppress the Expression of MMP‐1, TIMP‐1, and Cathepsin L, But Not Cathepsin B in Cultured Gingival Fibroblasts

Abstract

The results indicate that, besides suggested effects of these drugs on gingival fibroblasts and/or on accumulated cells in the gingival tissues, extracellular matrix-degrading ability, particularly that by cathepsin L, is also suppressed by cyclosporin A and phenytoin in gingival fibroblasts, and that lysosomal enzyme plays an important role in the pathogenesis of drug-induced gingival hyperplasia.