Mapping the Agonist Binding Site of the Nicotinic Acetylcholine Receptor by Cysteine Scanning Mutagenesis: Antagonist Footprint and Secondary Structure Prediction

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Katjuša Brejc, Willem J. van Dijk, Remco V. Klaassen et al. · Nature · 2001 · 1.8K citations

Life Sciences, Biophysics, Molecular Biology +17

[8] Substituted-cysteine accessibility method

Arthur Karlin, Myles H. Akabas · Methods in enzymology on CD-ROM/Methods in enzymology · 1998 · 585 citations

Natural Sciences, Biochemistry, Chemistry +3

A glia-derived acetylcholine-binding protein that modulates synaptic transmission

August B. Smit, Naweed I. Syed, Dick Schaap et al. · Nature · 2001 · 567 citations

Life Sciences, Neurobiology, Neuroscience +14

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

Myles H. Akabas, Christine Kaufmann, Patrick Archdeacon et al. · Neuron · 1994 · 430 citations

Life Sciences, Biochemistry, Biophysics +16

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site.

Peter N. Kao, Andrew J. Dwork, R R Kaldany et al. · Journal of Biological Chemistry · 1984 · 410 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17