Synthesis and Functionalization of New Tropanes Designed for Use as Scaffolds in Combinatorial Chemistry

Abstract

The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrroles and α,α′-dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studied. It is demonstrated that such tropanes represent potentially useful scaffolds.