Synthesis, DNA Binding, Hemolysis Assays and Anticancer Studies of Copper(II), Nickel(II) and Iron(III) Complexes of a Pyrazoline-Based Ligand

Abstract

DNA binding constants for ligand, copper, nickel and iron complexes were 1.42 × 10(4), 3.16 × 10(4), 5.82 × 10(5) and 6.72 × 10(5) M(-1), respectively, indicating strong binding with DNA. All the reported compounds were slightly hemolytic towards rabbit red blood corpuscles and exhibited moderate activities against MCF-7 cancer cell lines.