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EVALUATION OF CHLORMADINONE ACETATE AND OTHER PROGESTOGENS FOR FOETAL MASCULINIZATION IN RATS
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1963
Year
Hormonal ContraceptiveFertility6α-Chloro-pregna-4,6-diene-17α-ol-3,20-dione AcetateReproductive HealthFemale Reproductive SystemFemale Reproductive FunctionMenstrual CycleReproductive BiologyEmbryologyReproductive EndocrinologyFemale InfertilityReproductive MedicinePublic Health6α-Methyl-17α-hydroxyprogesterone AcetateInfertilityHormonal Male ContraceptionEndocrinologyPharmacologyOvarian HormoneDevelopmental BiologyAbstract Chlormadinone AcetatePhysiologyUterine ReceptivityMedicineReproductive Hormone
ABSTRACT Chlormadinone acetate (6α-chloro-pregna-4,6-diene-17α-ol-3,20-dione acetate) was administered subcutaneously to rats in the latter third of pregnancy. In doses up to 10 mg/day it did not produce any foetal masculinization of female pups as judged by the anogenital distance and gross observation of the sex structures. A significant increase in the average anogenital distances was produced by 6α-methyl-17α-hydroxyprogesterone acetate and a marked increase in the number of female pups with abnormally large anogenital distances was observed. 17α-ethyl-19-nortestosterone also increased the frequency of abnormally large anogenital distances in female offspring.