Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Ida Johansson, E Lundqvist, Leif Bertilsson et al. · Proceedings of the National Academy of Sciences · 1993 · 647 citations

Medicine, Genetics, Molecular Genetics +17

Effective amplification of long targets from cloned inserts and human genomic DNA.

S Cheng, Carita Fockler, Wayne M. Barnes et al. · Proceedings of the National Academy of Sciences · 1994 · 638 citations

Life Sciences, Molecular Biology, Molecular Genetics +14

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

Inger Johansson, Mikael Oscarson, Qun‐Ying Yue et al. · Molecular Pharmacology · 1994 · 430 citations

Medicine, Genetics, Molecular Genetics +16

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

Shioko Kimura, M Umeno, Radek C. Skoda et al. · PubMed · 1989 · 407 citations

Medicine, Genetics, Molecular Genetics +12

Nomenclature for human CYP2D6 alleles

Ann K. Daly, Jürgen Brockmöller, Franck Broly et al. · Pharmacogenetics · 1996 · 400 citations

Life Sciences, Genetics, Molecular Genetics +13