USE OF ADJUVANTS IN STUDIES ON INFLUENZA IMMUNIZATION

Abstract

Studies dealing with the application to man of influenza virus vaccines emulsified in a mineral oil of low viscosity have been in progress for several years. The data derived in the course of these investigations have significance not only for the problem of influenza immunization but for others of a similar nature. A summary of new data is reported here because the experience with influenza virus vaccines emulsified in light mineral oil was an important factor in facilitating the extension in human subjects of studies with experimental poliomyelitis vaccines; a report of the latter appeared inThe JournalMarch 28 (page 1081). There are discussions in the earlier papers of this series¹and in another recent report²of the problem involved in the development of a vaccine for influenza that would be effective against the immunologically different types as well as the different strains within each type. In