Biochemically Silent Abdominal Paragangliomas in Patients with Mutations in the <i>Succinate Dehydrogenase Subunit B</i> Gene

Abstract

Patients with SDHB mutations may present with biochemically silent abdominal PGLs due to defective catecholamine synthesis resulting from the absence of tyrosine hydroxylase. Screening for tumors in patients with SDHB mutations should not be limited to biochemical tests of catecholamine excess.