Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus

Abstract

The feeding of radiolabelled ornithine and arginine to mutants of Streptomyces clavuligerus auxotrophic for arginine has shown that ornithine has to be converted to arginine prior to incorporation into clavulanic acid.