Concepedia

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

Karson S. Putt, Grace W Chen, Jennifer M. Pearson, Joseph S Sandhorst, Martin S. Hoagland, Jung‐Taek Kwon, Soon-Kyung Hwang, Hua Jin, Mona I. Churchwell, Myung‐Haing Cho,

Nature Chemical Biology · 2006 · 348 citations · 25 references

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25

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Jialun Wang, Dongxiang Liu, Zhijia Zhang et al. · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations

, , +17

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

Marı́a S. Soengas, Paola Capodieci, David Polsky et al. · Nature · 2001 · 959 citations

, , +14

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

Henning R. Stennicke, Juliane M. Jürgensmeier, Hwain Shin et al. · Journal of Biological Chemistry · 1998 · 751 citations · Full text

, , +12

A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

Li Lin, Ranny Mathew Thomas, Hidetaka Suzuki et al. · Science · 2004 · 658 citations

, , +17