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Total synthesis of the antileukaemic lignan (±)-steganacin
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0
References
1977
Year
Synthetic RouteMedicinal ChemistryAntileukaemic LignanBioorganic ChemistryDerivativesBiochemistryPharmaceutical ChemistryNatural SciencesDerivative (Chemistry)Total SynthesisOrganic ChemistryHeterocycle ChemistryPharmacologyBiphenyl SystemSynthetic ChemistryNatural Product Synthesis
A synthetic route to the antileukaemic lignan (±)-steganacin (1) is described from the readily available piperonal and 3,4,5-trimethoxyphenylacetic acid. Diastereoisomerism encountered in a number of precursors has been ascribed unambiguously to the presence of the bridged biphenyl system (atropisomerism).