Concepedia

Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential S<sub>N</sub>2–S<sub>N</sub>2′ dialkylation of (R)-N-(benzyl)proline-derived glycine Schiff base Ni(<scp>ii</scp>) complex

Aki Kawashima, Chen Xie, Haibo Mei, Ryosuke Takeda, Akie Kawamura, Tatsunori Sato, Hiroki Moriwaki, Kunisuke Izawa, Jianlin Han, José Luis Aceña,

RSC Advances · 2014 · 33 citations · 85 references

DOI

Concepts

Abstract

The synthesis of the title compound, a key structural fragment of several hepatitis C virus inhibitors, is described.

References

85

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Douglas O. Adams, Shang Fa Yang · Proceedings of the National Academy of Sciences · 1979 · 1.4K citations · Full text

, , +11

Peptidomimetics—Tailored Enzyme Inhibitors

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Design of peptides, proteins, and peptidomimetics in chi space

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, , +17

Cyclopropane amino acids

Charles H. Stammer · Tetrahedron · 1990 · 308 citations

Recent progress on the stereoselective synthesis of cyclic quaternary α-amino acids

Carlos Cativiela, Mario Ordóñez · Tetrahedron Asymmetry · 2009 · 276 citations · Full text

, , +13