Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential S<sub>N</sub>2–S<sub>N</sub>2′ dialkylation of (R)-N-(benzyl)proline-derived glycine Schiff base Ni(<scp>ii</scp>) complex - Concepedia

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Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential S<sub>N</sub>2–S<sub>N</sub>2′ dialkylation of (R)-N-(benzyl)proline-derived glycine Schiff base Ni(<scp>ii</scp>) complex

31

Citations

85

References

2014

Year

Aki Kawashima, Chen Xie, Haibo Mei, Ryosuke Takeda, Akie Kawamura, Tatsunori Sato, Hiroki Moriwaki, Kunisuke Izawa, Jianlin Han, José Luis Aceña,

Bioorganic ChemistryOrganic ChemistryChemistryAntiviral DrugTitle CompoundPharmaceutical ChemistryKey Structural FragmentMedicinal Chemistry-1-Amino-2-vinylcyclopropanecarboxylic AcidAntiviral Drug DevelopmentBiochemistryAsymmetric SynthesisPharmacologyAntiviral CompoundEnantioselective SynthesisBiomolecular EngineeringNatural SciencesAntiviral TherapyHepatitisMedicineSynthetic ChemistryDrug Discovery

Abstract

The synthesis of the title compound, a key structural fragment of several hepatitis C virus inhibitors, is described.

References

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