Enantioselective Radical Addition/Trapping Reactions with α,β-Disubstituted Unsaturated Imides. Synthesis of<i>a</i><i>nti</i>-Propionate Aldols

Abstract

This manuscript describes a highly diastereo- and enantioselective intermolecular radical addition/hydrogen atom transfer to alpha,beta-disubstituted enoates. Additionally, we show that anti-propionate aldol-like products can be easily prepared from alpha-methyl-beta-acyloxyenoates in good yields and high diastereo- and enantioselectivities.