Dynamics of Cytomegalovirus (CMV)–Specific T Cells in HIV‐1–Infected Individuals Progressing to AIDS with CMV End‐Organ Disease

Abstract

Our data indicate that insufficient help of CD4(+) T cells may cause loss of IFN- gamma -producing CD8(+) T cells and loss of control of CMV dissemination. Increasing CMV-infected cell counts in the face of high CMV-specific perforin- and granzyme B-expressing CD8(+) T cell counts may explain the immune pathological characteristics of CMV disease.