Journal of Combinatorial Chemistry · 2005 · 46 citations · 19 references
PharmacyMedicinal ChemistryCombinatorial ChemistryDrug DiscoverySynthetic Medicinal ChemistryCombinatorial SynthesisHeterocycle SynthesisParallel SynthesisSolid-phase SynthesisSolution-phase SynthesisParallel Synthesis MethodologyParallel Synthesis Of HeterocyclesSolid-phase Library SynthesisSolid-phase Parallel SynthesisSolution-phase Parallel Synthesis
On the basis of the enaminone methodology, libraries of 3-amino-4H-quinolizin-4-ones, fused 3-amino-4H-pyrimidin-4-ones, and fused 3-amino-2H-pyran-2-ones were synthesized by the solid-phase and by the solution-phase parallel synthesis. The solution-phase approach turned out to be advantageous over the solid-phase approach. The solution-phase synthesis afforded, in most cases, analytically pure products in high yields, whereas the solid-phase approach gave products in poor yields and in low purity.
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