Proceedings of the National Academy of Sciences · 1976 · 242 citations · 16 references
Viral ReplicationViral Polymerase StructureViral Polymerase MechanismMolecular BiologyVirus StructurePoliovirus RnaVirus GeneViral GeneticsDna ReplicationVirologyGene ExpressionPoliovirus Polyribosomal RnaMolecular VirologyNatural SciencesPathogenesisRna SpeciesMicrobiologyVirus-specific PolyribosomesMedicine
Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of poliovirus RNA. We conclude that a 5'-terminal m7G is not required for translation of at least one RNA species in animal cells.
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Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-.
Yasuhiro Furuichi, Michael K. Morgan, Subbaratnam Muthukrishnan et al. · Proceedings of the National Academy of Sciences · 1975 · 352 citations · Full text
Terminal Nucleotide Linkage, Viral Replication, Viral Polymerase Structure +17