Proceedings of the National Academy of Sciences · 1975 · 353 citations · 21 references
Life SciencesMicrobiologyMolecular BiologyMolecular VirologyNucleic Acid BiochemistryVirologyRna StructureViral Gene ExpressionViral GeneticsViral Rna BiologyViral StructureViral TranscriptionS-adenosylmethionine MetabolismS-adenosylmethionine-dependent MethylationViral Mrna PolyadenylationViral Nucleocapsid StructureViral Polymerase GenesViral PolymerasesViral Rna StructureViral Rna Transcription
Reovirus mRNA synthesized in vitro by the virus-associated RNA polymerase in the presence of S-adenosylmethionine contains blocked, methylated 5'-termini with the structure, m-7G(5')ppp(5')G-MpCp. The functional significance and possible mechanism of formation of this novel 5'-5' terminal nucleotide linkage are discussed.
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