Publication | Open Access
Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-.
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Citations
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References
1975
Year
Terminal Nucleotide LinkageViral ReplicationViral Polymerase StructureViral Polymerase MechanismImmunologyMolecular BiologyViral Structural ProteinVirus StructureVirus GeneViral GeneticsBiochemistryReovirus Messenger RnaVirus-associated Rna PolymeraseDna ReplicationVirologyGene ExpressionReovirus MrnaNatural SciencesPathogenesisMedicine
Reovirus mRNA synthesized in vitro by the virus-associated RNA polymerase in the presence of S-adenosylmethionine contains blocked, methylated 5'-termini with the structure, m-7G(5')ppp(5')G-MpCp. The functional significance and possible mechanism of formation of this novel 5'-5' terminal nucleotide linkage are discussed.
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