Concepedia

cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein

Joan D. Ferraris, Prita Persaud, Chester K. Williams, Ye Chen, Maurice B. Burg

Proceedings of the National Academy of Sciences · 2002 · 98 citations · 18 references

DOI

Abstract

(i) PKA plays an important role in TonEBP/OREBP activation of tonicity-dependent gene expression; (ii) PKA activation of TonEBP/OREBP appears to be cAMP-independent; and (iii) amino acids 872-1271 are sufficient for tonicity-dependent transactivation of TonEBP/OREBP.

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Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity

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