The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Medicine, Molecular Biology, Oncology +10

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F. Easton, Karen A. Pooley, Alison M. Dunning et al. · Nature · 2007 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +12

Amplification of a gene encoding a p53-associated protein in human sarcomas

Jonathan D. Oliner, Kenneth W. Kinzler, Paul S. Meltzer et al. · Nature · 1992 · 2K citations · Full text

Medicine, Genetics, Molecular Genetics +12

JASPAR: an open-access database for eukaryotic transcription factor binding profiles

Albin Sandelin · Nucleic Acids Research · 2003 · 1.8K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Gareth L. Bond, Wenwei Hu, Elisabeth E. Bond et al. · Cell · 2004 · 1.3K citations · Full text

Medicine, Genetics, Molecular Genetics +15