Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.8K citations

Social Sciences, Behavioral Sciences, Psychology +9

Behavioural despair in rats: A new model sensitive to antidepressant treatments

Roger D. Porsolt, Guy Anton, N. Blavet et al. · European Journal of Pharmacology · 1978 · 3.1K citations

Medicine, Behavioral Sciences, Neurobiology +13

Negative v Positive Schizophrenia

Nancy C. Andreasen · Archives of General Psychiatry · 1982 · 2K citations

Medicine, Psychiatry, Adult Psychiatry +16

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Paul Willner, Anthony Towell, D. Sampson et al. · Psychopharmacology · 1987 · 2K citations

Medicine, Behavioral Sciences, Pharmacology +15

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V _1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders

Guy Griebel, Jacques Simiand, Claudine Serradeil‐Le Gal et al. · Proceedings of the National Academy of Sciences · 2002 · 462 citations · Full text

Medicine, Neuroscience, Pharmacology +17