Designing better coumarin-based fluorogenic substrates for PTP1B

Molecular Basis for the Dephosphorylation of the Activation Segment of the Insulin Receptor by Protein Tyrosine Phosphatase 1B

Annette Salmeen, Jannik N. Andersen, Michael P. Myers et al. · Molecular Cell · 2000 · 464 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design

Yoram A. Puius, Yu Zhao, Michael Sullivan et al. · Proceedings of the National Academy of Sciences · 1997 · 402 citations

Life Sciences, Biochemistry, Molecular Biology +17

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

Sofi G. Julien, Nadia Dubé, Michelle Read et al. · Nature Genetics · 2007 · 320 citations

Medicine, Molecular Biology, Oncology +16

Structure-Based Optimization of Protein Tyrosine Phosphatase 1B Inhibitors:  From the Active Site to the Second Phosphotyrosine Binding Site

Douglas Wilson, Zhao‐Kui Wan, Weixin Xu et al. · Journal of Medicinal Chemistry · 2007 · 164 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structural Basis for Inhibition of the Protein Tyrosine Phosphatase 1B by Phosphotyrosine Peptide Mimetics^,

Matthew R. Groves, Zhu‐Jun Yao, Peter P. Roller et al. · Biochemistry · 1998 · 123 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17