Appetite suppression and weight loss after the cannabinoid antagonist SR 141716

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

William A. Devane, Aviva Breuer, Roger G. Pertwee et al. · Science · 1992 · 5.6K citations

Life Sciences, Neuroscience, Pharmacology +15

Determination and characterization of a cannabinoid receptor in rat brain.

William A. Devane, F A Dysarz, M R Johnson et al. · Molecular Pharmacology · 1988 · 2.4K citations

Medicine, Neuroscience, Pharmacology +12

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

Murielle Rinaldi‐Carmona, Francis Barth, Michel Héaulme et al. · FEBS Letters · 1994 · 1.8K citations · Full text

Medicine, Neuroscience, Pharmacology +14

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors

M. Arnone, Jeanne Maruani, Frédérique Chaperon et al. · Psychopharmacology · 1997 · 595 citations

Medicine, Neuroscience, Pharmacology +13

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity.

David M. Compton, Mario D. Aceto, John Lowe et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 360 citations

Medicine, Medicinal Chemistry, Pharmacology +10