Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Dae‐Kyun Ro, Eric M. Paradise, Mario Ouellet et al. · Nature · 2006 · 2.8K citations

Life Sciences, Biological Engineering, Biotechnology +12

<i>Artemisia annua</i> L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin

Keat H. Teoh, Devin R. Polichuk, Darwin W. Reed et al. · FEBS Letters · 2006 · 412 citations · Full text

Life Sciences, Plant Biology, Plant Sciences +17

Is the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase a Rate-Limiting Step for Isoprenoid Biosynthesis in Plants?

Joe Chappell, F. Wolf, Jacques Proulx et al. · PLANT PHYSIOLOGY · 1995 · 334 citations

Life Sciences, Biochemistry, Plant Sciences +15

Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

P. Mercke, Marie Bengtsson, Harro J. Bouwmeester et al. · Archives of Biochemistry and Biophysics · 2000 · 284 citations

Life Sciences, Botany, Plant Sciences +13

Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin

T. Eelco Wallaart, Harro J. Bouwmeester, Jacques Hille et al. · Planta · 2001 · 242 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11