XANTHOMATOSIS AND THE RETICULOENDOTHELIAL SYSTEM

Abstract

Pathologic Considerations Pathogenesis in Relation to Hyperlipoidemia and the Reticulo-Endothelial System CONTENTS Introduction. Report of Cases. Resume of Cases Showing Christian's Syndrome. Christian's Syndrome and Xanthomatosis. Historical Consideration of Xanthoma in Relation to Christian's Syndrome. Constituion General Account General comment of the Symptomologic considerations Clinical Picture Clinical and symptomologic considerations concerning syndrome Microscopic changes Microscopic and clinical changes Microscopic changes concerning the syndrome Study of microscopic changes—conclusions Pathogenic theories Hypercholesterinemia Hyperlipoidemia—clinical consideration Hypercholesterinemia and animal experimentation The reticulo-endothelial system and xanthomatosis General Comment in Relation to the Syndrome. Conclusions regarding pathogenesis. Conditions that should be included as manifestations of a general disturbance of lipoid metabolism. The nature of the nodular lesions. Clinical features in general. Summary and Conclusions. INTRODUCTION Xanthoma was first described as a rare disease of the skin. It is still classed as a dermatologic condition, although for a long time it has, in all its many