Propofol Decreases Myofilament Ca2+Sensitivity via a Protein Kinase C–, Nitric Oxide Synthase–dependent Pathway in Diabetic Cardiomyocytes

Abstract

Myofilament Ca2+ sensitivity and, to a lesser extent, peak [Ca2+]i are decreased in diabetic cardiomyocytes. Increases in PKC and NOS expression in combination with TnI phosphorylation seem to contribute to the decrease in [Ca2+]i and myofilament Ca2+ sensitivity. Propofol decreases [Ca2+]i and shortening via a PKC-, NOS-dependent pathway.