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Synthesis of Hybrids of <scp>D</scp>‐Glucose and <scp>D</scp>‐Galactose with Pyrrolidine‐Based Iminosugars as Glycosidase Inhibitors
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Citations
44
References
2008
Year
Bioorganic ChemistryEngineeringD ‐GlucoseGlycobiologyPolysaccharideModerate Glycosidase InhibitorsEnzymatic ModificationMedicinal ChemistryBiosynthesisGlycosidase InhibitorsGlycosylationGlycal EpoxidesBiochemistryBiocatalysisPyrrolidine‐based IminosugarsPharmacologyBiomolecular EngineeringNatural SciencesBiotechnologyCarbohydrate-protein Interaction
Abstract Sugar–iminosugar hybrid molecules made up of D ‐glucose and D ‐galactose with pyrrolidine‐based iminosugars, viz. 1,4‐dideoxy‐1,4‐imino‐ L ‐xylitol and 1,4‐dideoxy‐1,4‐imino‐ L ‐lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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