Induction of Nuclear Androgen-Binding Sites in Epithelium of the Embryonic Urinary Bladder by Mesenchyme of the Urogenital Sinus of Embryonic Mice*

Abstract

Mesenchyme of the embryonic urogenital sinus induces epithelium of the embryonic urinary bladder to form prostatic acini. The induced glandular epithelium exhibits nuclear androgen-binding sites, as demonstrated autoradiographically. This suggests that the expression of androgen receptor activity in an epithelium is dependent upon the mesenchyme with which it is associated during development.