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Monoclonal Antibodies That Label Discrete Cell Types in the Mammalian Nervous System
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1983
Year
Immunocytochemical TechniqueNeurogenomicsCircuit NeuroscienceSynaptic TransmissionImmunologyImmunophenotypingNeurodevelopmentBasic NeurosciencePeripheral NervesCellular NeurobiologySynaptic SignalingCellular PhysiologySocial SciencesAntibody EngineeringNeuroimmunologyNeurological FunctionMammalian Nervous SystemPhysiological ComplexityMolecular NeuroscienceBrain-immune InteractionNervous SystemCell BiologyDevelopmental BiologyNeurophysiologyNeuroanatomyCellular NeuroscienceNeural CircuitsNeuroscienceMolecular NeurobiologyCentral Nervous SystemCentral Nervous System BiologyMonoclonal AntibodiesMedicine
Anatomical and electrophysiological studies have elucidated some of the morphological and physiological complexity of many areas of the CNS. From these studies, it is now possible to construct rudimentary “wiring diagrams” to explain the ways in which some information is processed. However, the cellular and molecular events underlying either the development or the function of any area of the CNS are not yet understood in any detail. Two of the recent tools of molecular biology, namely, monoclonal antibodies and recombinant DNA molecules, offer the possibility of defining some of the molecules of importance in the nervous system.