Chlorinative Cyclization of 1,6‐Enynes by Enantioselective Palladium(II)/Palladium(IV) Catalysis

Abstract

Abstract A novel asymmetric catalysis via a palladium(II)/palladium(IV) cycle has been developed by utilizing a chiral spiro bis(isoxazoline) ligand (SPRIX). Intramolecular chlorinative cyclization of 1,6‐enynes catalyzed by a palladium‐SPRIX complex proceeded enantioselectively to afford α‐methylene‐γ‐lactone derivatives.