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A General Strategy for the Synthesis of Monohydroxy-eicosatetraenoic Acids: Total Synthesis of 5(<i>S</i>)-Hydroxy-6(<i>E</i>),8,11,14(<i>Z</i>)-eicosatetraenoic Acid (5-HETE) and 12(<i>S</i>)-Hydroxy-5,8,14(<i>Z</i>), 10(<i>E</i>)-eicosatetraenoic Acid (12-HETE)
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1986
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Chemical EngineeringBiosynthesisGeneral StrategyEngineeringBiochemistryCross-coupling ReactionNatural SciencesDiversity Oriented SynthesisDiversity-oriented SynthesisMonohydroxy-eicosatetraenoic AcidsTotal SynthesisOrganic ChemistryStereoselective SynthesisChemistryTotal SynthesesSynthetic ChemistryEnantioselective SynthesisNatural Product Synthesis
Stereocontrolled total syntheses of 5(S)-hydroxy-6(E),8, 11,14(Z)-eicosatetraenoic acid (5-HETE) and 12(S)hydroxy-5,8,14 (Z), 10(E)-eicosatetraenoic acid (12-HETE) via palladium(0)-copper(I) coupling technology are described.