NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Hsp90 as a capacitor for morphological evolution

Suzanne L. Rutherford, Susan Lindquist · Nature · 1998 · 2.3K citations

Molecular Biological Method, Protein Folding, Signal Recognition +5

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Toshiyuki Araki, Yo Sasaki, Jeffrey Milbrandt · Science · 2004 · 1.1K citations

Protein disaggregation mediated by heat-shock protein Hspl04

Dawn A. Parsell, Anthony S. Kowal, Mike A. Singer et al. · Nature · 1994 · 869 citations

Protein Chemistry, Protein Function, Protein Folding +2

A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration

Janghoo Lim, Tong Hao, Chad A. Shaw et al. · Cell · 2006 · 787 citations · Full text

Purkinje Cell Degeneration, Neurodegenerative Diseases, Molecular Neuroscience +14

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

Christopher J. Cummings, Michael A. Mancini, Barbara Antalffy et al. · Nature Genetics · 1998 · 742 citations

Protein Function, Protein Assembly, Protein Folding +9