The effects of nitric oxide on <i>Staphylococcus aureus</i> biofilm growth and its implications in chronic rhinosinusitis

Abstract

S. aureus biofilm formation varies across exposure to different NO levels, with antibiofilm effects at higher concentrations, and enhanced biofilm formation at lower or subphysiologic concentrations. These results coincide with the often dualistic function of NO, and have implications in its future use in the treatment of CRS.